The Relation of Certain Bacteria to Non-specific Reactions with the Complement Fixation Test for Lues
نویسنده
چکیده
Several investigators who have had a large experience with the complement fixation test for lues have called attention to the development in sera of anticomplementary bodies which cause inhibition of hemolysis in both the antigen and control tubes, and they have found that in most instances this property of the serum is lost after heating it for half an hour at 560 C. In some instances, however, the property still persists after heating, and in such sera one is unable to read the reaction. It would appear from these observations that the anticomplementary bodies are of two kinds, thermolabile and thermostabile, and that the inactivation of serum enables us to destroy only the thermolabile group. The exact nature of these anticomplementary substances is still in doubt, but it is the purpose of this contribution to show that certain strains of bacteria, if growing in human blood serum, are capable of producing total inhibition of hemolysis in both antigen and control tubes ; and that not only is this true, but certain bacteria also possess the power of producing inhibition in the antigen tubes alone, thus giving rise to a non-specific reaction in the sera which contain them. In the application of the complement fixation to the diagnosis of lues in the military service, we have adopted in this laboratory the modification of the Wassermann test devised by Noguchi, the only departure from his technique being the use of an alcoholic extract of fetal luetic liver as antigen, and the inactivation of the serum
منابع مشابه
Observations upon the Noguchi Modification of the Wassermann Complement Fixation Test in the Diagnosis of Lues in the Military Service
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 13 شماره
صفحات -
تاریخ انتشار 2003